ملخص: The three:component coupling of an 1,2:aminoalcohol, a 1,2:dicarbonyl compound and a boronic acid was investigated. The reaction is supposed to proceed through the formation of a heterocyclic iminium species followed by the addition of the organoboron derivative. The diastereoselectivity of this process is discussed. Best results were observed when the probable intermediate was generated from a preformed 3:phenylthiomorpholin:2:ol. Products of this three:component boro:Mannich could be readily converted to the corresponding aminodiols by reduction with lithium aluminium hydride.

لغة: فرنسية