ملخص: This study was aimed at determining the effects of systemic administration of diazepam and methyl beta-carboline-3-carboxylate ([beta]-CCM) both on spatial working memory and on emotional reactivity in mice. Results showed that diazepam and [beta]-CCM induced opposite effects in both memory and emotional reactivity tests. Indeed, as a function of dose, diazepam reduced anxiogenic-like reactions but increased vulnerability to interference in the memory task at a 30-s but not at a 5-s delay interval. As a function of dose, [beta]-CCM reduced vulnerability to interference and increased emotional reactivity, these effects being antagonised by concurrent administration of flumazenil (RO 15-1788). Thus, our study showed the bidirectional effects of these two drugs on a spatial working memory task involving a spontaneous processing of information and suggested a direct link between the emotional effects of the drugs and memory performance.

لغة: إنجليزية