ملخص: The prevalence of Epstein-Barr virus (EBV) markers in nodal lesions from Algerians (Al) patients (n = 68) was compared to French (Fr) patients (Pts) (n = 21) with Hodgkin's disease. Initial characteristics were: males Fr 57%, Al 53%; median age Fr 29, Al 25; histologic subtypes: lymphocytic predominance (LP) Fr 1, Al 3; nodular sclerosis (NS) Fr 16, Al 33; mixed cellularity (MC) Fr 4, Al 30; lymphocytic depletion (LD) Al 2.The latent membrane protein (LMP) expression was founded in Reed-Sternberg cells (RSC) in 26 cases Al (1 PL, 8 NS, 17 MC) and 4 Fr (2 NS, 2 MC). All cases LMP-positive were also by DNA or RNA in situ hybridization (ISH). ISH was positive in RSC of 29% of Fr and 66% of Al Pts (P More pronounced ISH positivity in Al young adult cases (P < 0.05) can result from the age at primary EBV infection, which occurs earlier in Algeria than in France.

لغة: إنجليزية